PearsonSolver: Create a Solver class object using Pearson correlation...

In trena: Fit transcriptional regulatory networks using gene expression, priors, machine learning

Description

Create a Solver class object using Pearson correlation coefficients as the solver

Usage

PearsonSolver(
  mtx.assay = matrix(),
  targetGene,
  candidateRegulators,
  quiet = TRUE
)

Arguments

mtx.assay	An assay matrix of gene expression data
targetGene	A designated target gene that should be part of the mtx.assay data
candidateRegulators	The designated set of transcription factors that could be associated with the target gene
quiet	A logical denoting whether or not the solver should print output

Value

A Solver class object with Pearson correlation coefficients as the solver

See Also

solve.Pearson, getAssayData

Other Solver class objects: BayesSpikeSolver, EnsembleSolver, HumanDHSFilter-class, LassoPVSolver, LassoSolver, RandomForestSolver, RidgeSolver, Solver-class, SpearmanSolver, XGBoostSolver

Examples

load(system.file(package="trena", "extdata/ampAD.154genes.mef2cTFs.278samples.RData"))
target.gene <- "MEF2C"
tfs <- setdiff(rownames(mtx.sub), target.gene)
pearson.solver <- PearsonSolver(mtx.sub, target.gene, tfs)

trena documentation built on Nov. 15, 2020, 2:07 a.m.