findOutliers.func: Function to identify outlier clones

Description Usage Arguments Details Value Author(s) References See Also

View source: R/hmm.R

Description

The function identified the clones that are outliers.

Usage

1
findOutliers.func(thres, factor = 4, statesres)

Arguments

thres

Estimate of experimental variability, generally, madGenome

factor

Factor indicating how many standard

statesres

The states output of the hmm.run.func

Details

The outliers are the clones that are dissimilar enough from the clones assigned to the same state. Magnitude of the factor determines how many MADs away from a median a value needs to be to be declared an outlier. Outliers consitent over many samples may indicate technological artificat with that clone or possibly copy number polymorpism.

Value

outlier

Binary matrix with a row for each clone and column for each sample. "1" indicates outlier, 0 otherwise.

pred.obs.out

Matrix with a row for each clone and column for each sample. The entries are the median value for the state with outliers exceluded for all clones but outliers. The value if the observed value for the outliers.

pred.out

Matrix with a row for each clone and column for each sample. The entries are the median value for the state

Author(s)

Jane Fridlyand

References

Application of Hidden Markov Models to the analysis of the array CGH data, Fridlyand et.al., JMVA, 2004

See Also

aCGH


aCGH documentation built on Nov. 8, 2020, 6:58 p.m.