Description Details Author(s) References See Also
sQTLseekeR2 tests for association between genetic variants and alternative splicing (relative transcript abundances of a gene measured from RNA-seq), using a multivariate non-parametric approach. It is an enhanced version of sQTLseekeR (see Details).
Main enhancements in sQTLseekeR2:
Covariate correction
Faster pre-processing of transcript expression
Improved P-value calculation with higher precision
Permutation-based schema for multiple testing correction
LD-based variant clustering
Diego Garrido-Martín, Jean Monlong, Miquel Calvo, Ferran Reverter, Roderic Guigó
Garrido-Martín, D. et al. Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome. Nat Commun 12, 727 (2021). https://doi.org/10.1038/s41467-020-20578-2
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