BaselineCorrectionSD: Baseline correction for the dose-response matrix of drug...

In struckma/synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Description

A function to do baseline correction on the dose-response matrix for drug combinations with a weighted correction fator

Usage

BaselineCorrectionSD(response.mat, Emin = NA, Emax = NA,
  nan.handle = c("LL4", "L4"))

Arguments

response.mat	a dose-response matrix with concentrations as row names and column names.
Emin	the minimal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA.
Emax	the maximal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA.
nan.handle	a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs.

Value

A list of the original dose-response matrix without correction and the corrected dose-response matrix.

Author(s)

Liye He [e-mail], Jing Tang [e-mail]

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
data <- BaselineCorrectionSD(data$dose.response.mats[[1]])

struckma/synergyfinder documentation built on May 17, 2019, 11:18 p.m.