Description Usage Arguments Value Author(s)
Finds best local alignment for two PWMs.
1 2 3 4 | localPwmAlignment(pwm_left, pwm_right, divergence = shannonDivergence,
unaligned_penalty = divergencePenaltyForUnaligned,
try_reverse_complement = TRUE, base_distribution = NULL,
length_normalization = FALSE)
|
pwm_left |
first PWM, a matrix of type matrix |
pwm_right |
first PWM, a matrix of type matrix |
divergence |
is a measure of difference between two pwm columns. Smaller is more similar. If you want to use non-uniform background distribution, provide your own function. |
unaligned_penalty |
distance for unaligned columns at edges of matrixes. See divergencePenaltyForUnaligned as an example for providing your own function |
try_reverse_complement |
If false the alignment will not be performed on reverse complements. If true, the input pwms should have column order of ACTG/ACGU. |
base_distribution |
is a vector of length nrow(pwm) that is added to unaligned columns of pwms for comparing. If NULL, uniform distribution is used |
length_normalization |
If true, will minimize the average divergence between PWMs. Otherwise will minimize the sum of divergences between positions. In both cases unalignes positions are compared to base_distribution and are counted when computing the alignment length. |
list of length two containing the alignment and the divergence
Lando Andrey
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