broadinstitute/PerturbationAMARETTO: Regulatory Network Inference and Driver Gene Evaluation using Integrative Multi-Omics Analysis and Penalized Regression
Integrating an increasing number of available multi-omics cancer data remains one of the main challenges to improve our understanding of cancer. One of the main challenges is using multi-omics data for identifying novel cancer driver genes. We have developed an algorithm, called AMARETTO, that integrates copy number, DNA methylation and gene expression data to identify a set of driver genes by analyzing cancer samples and connects them to clusters of co-expressed genes, which we define as modules. We applied AMARETTO in a pancancer setting to identify cancer driver genes and their modules on multiple cancer sites. AMARETTO captures modules enriched in angiogenesis, cell cycle and EMT, and modules that accurately predict survival and molecular subtypes. This allows AMARETTO to identify novel cancer driver genes directing canonical cancer pathways.
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Package details |
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| Author | Jayendra Shinde, Celine Everaert, Shaimaa Bakr, Mohsen Nabian, Jishu Xu, Vincent Carey, Nathalie Pochet and Olivier Gevaert |
| Bioconductor views | AlternativeSplicing BatchEffect Bayesian Clustering CopyNumberVariation DataImport DifferentialExpression DifferentialMethylation DifferentialSplicing ExonArray GeneExpression GeneRegulation GeneSetEnrichment MethylationArray MicroRNAArray Microarray MultipleComparison Network Normalization OneChannel Preprocessing ProprietaryPlatforms QualityControl RNASeq Regression Sequencing StatisticalMethod TimeCourse Transcription TwoChannel mRNAMicroarray |
| Maintainer | Olivier Gevaert <olivier.gevaert@gmail.com> |
| License | Apache License (== 2.0) + file LICENSE |
| Version | 0.99.29 |
| Package repository | View on GitHub |
| Installation |
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