InteractionProgramSignificance: Test Interaction program statistical significance

In BlishLab/scriabin: Single-cell resolved interaction analysis through binning

Test Interaction program statistical significance

Description

Test Interaction program statistical significance

Usage

InteractionProgramSignificance(ip_data, n.replicate = 10000, min.members = 1)

Arguments

ip_data	Interaction program data, ie. the output of either InteractionPrograms or FindAllInteractionPrograms
n.replicate	Number of one-sided Mann-Whitney tests to perform to assess correlation of each module. Default: 10000
min.members	Minimum number of unique ligands or receptors in order to keep a module. Default: 1. Ie, if a module contains many ligand-receptor pairs that all share the same single ligand, this module will be discarded

Value

Returns a data.frame of all significant modules, their connectivity p-values for each sample, and their intramodular connectivity in each sample

BlishLab/scriabin documentation built on Sept. 16, 2024, 1:19 a.m.