getRefLimma: provide access to a limma analysis of RNA-seq profiles for...

Description Usage Value Note Examples

View source: R/data.R

Description

provide access to a limma analysis of RNA-seq profiles for reference histology samples

Usage

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Value

an instance of MArrayLM-class representing regularized gene-wise ANOVAs

Note

Uses download.file to acquire RDS of the output of eBayes from a public S3 bucket. The limma model was fit using duplicateCorrelation to address multiplicity of contributions per donor. Comparisons are to samples labeled CT-reference (cellular tumor, reference contributions), with coefficients 2-5 corresponding to CT-mvp (microvascular proliferation), CT-pan (pseudopalisading cells around necrosis), IT (infiltrating tumor), and LE (leading edge), respectively.

Examples

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requireNamespace("limma")
ebout = getRefLimma() # is result of eBayes
colnames(ebout$coef)
limma::topTable(ebout,2)

ivygapSE documentation built on Nov. 8, 2020, 8:08 p.m.