estimateDirichlet-methods: Learn a base-specific Dirichlet prior.

In deepSNV: Detection of subclonal SNVs in deep sequencing data.

Description

The prior learns the parameters of a Dirichlet distribution seperately for each consensus base. The expected value of the Dirichlet distributions is the base-substitution matrix, where rows correspond to the initial nucleotide and columns to the substituted nucleotide. The absolute values determine the higher moments of the Dirichlet distributions. After having learned the prior the deepSNV-class test is recomputed.

Usage

estimateDirichlet(control)

## S4 method for signature 'matrix'
estimateDirichlet(control)

## S4 method for signature 'deepSNV'
estimateDirichlet(control)

Arguments

control

Either a matrix with nucleotide counts or a deepSNV-class object.

Value

An deepSNV-class object.

Author(s)

Moritz Gerstung

Examples

data(phiX)
estimateDirichlet(phiX)

deepSNV documentation built on Nov. 8, 2020, 8:01 p.m.