ct.alphaBeta: Aggregation of P-value Ranks using a Beta Distribution and...
In OscarBrock/gCrisprTools: Suite of Functions for Pooled Crispr Screen QC and Analysis
ct.alphaBeta R Documentation
Aggregation of P-value Ranks using a Beta Distribution and Alpha Cutoff
Description
This function calculates an alpha-modified rho statistic from a set of normalized ranks by comparing them to a uniform distribution.
Specifically, the ranks are ordered and p-values calculated at each position in the ordered vector by comparison to a Beta distribution. The rho value
returned is the smallest p-value identified in this way across all scores. Should not be used by end users.
Usage
ct.alphaBeta(p.in)
Arguments
p.in
A single column matrix of rank scores, with row.names indicating the gRNA labels.
Value
A numeric rho value corresponding to the minimum rank order P.
Author(s)
Russell Bainer, modified from code from the RobustRankAggreg package.
Citation:
Kolde, R. et al, Bioinformatics. 2012 Feb 15;28(4):573-80. doi: 10.1093/bioinformatics/btr709.
Examples
testp <- runif(20)
ct.alphaBeta(testp)
OscarBrock/gCrisprTools documentation built on Oct. 25, 2022, 7:29 a.m.
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| ct.alphaBeta | R Documentation |
Aggregation of P-value Ranks using a Beta Distribution and Alpha Cutoff
Description
This function calculates an alpha-modified rho statistic from a set of normalized ranks by comparing them to a uniform distribution. Specifically, the ranks are ordered and p-values calculated at each position in the ordered vector by comparison to a Beta distribution. The rho value returned is the smallest p-value identified in this way across all scores. Should not be used by end users.
Usage
ct.alphaBeta(p.in)
Arguments
p.in |
A single column matrix of rank scores, with row.names indicating the gRNA labels. |
Value
A numeric rho value corresponding to the minimum rank order P.
Author(s)
Russell Bainer, modified from code from the RobustRankAggreg package.
Citation: Kolde, R. et al, Bioinformatics. 2012 Feb 15;28(4):573-80. doi: 10.1093/bioinformatics/btr709.
Examples
testp <- runif(20) ct.alphaBeta(testp)
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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