Function OVESEGtest
performs OVESEG-test for expression
profiles from multiple groups to detect subtype-specific marker genes.
While it may take a long time to execute permutations for p-value estimation,
users can apply OVESEGtstat
to obtain OVESEG-test statistics
to rank genes and apply postProbNull
to obtain each gene's
posterior probabilities of component null hypotheses.
nullDistri
estimates probabilities of any one group being
upregulated under null hypotheses.
patternDistri
estimates probabilities of all kinds of
upregulation patterns among groups.
Chen, L., Herrington, D., Clarke, R., Yu, G., and Wang, Y. (2019). “Data-Driven Robust Detection of Tissue/Cell-Specific Markers.” bioRxiv. https://doi.org/10.1101/517961.
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