REDUCE = c
to bpiterate()
mvTest()
for test of single coefficienteBayes()
to be comptabile with legacy
parameter added in limma
v3.62.0 mvTest()
for se
value with 1 feature[.MArrayLM2
dropping residuals to a vectormvTest()
with shrink.cov = TRUE
uses lambda = 0.01
mvTest()
return beta
and se
voomWithDreamWeights()
, default changed to rescaleWeightsAfter = FALSE
topTable()
resolve issue when specifying multiple coeffsvoomWithDreamWeights()
, add argument prior.count.for.weights
voomWithDreamWeights()
taking raw countsvoomWithDreamWeights()
, add argument priorWeightsAsCounts=FALSE
and prior.count.for.weights
dream(...,ddf="Kenward-Roger")
that gave false positives and negativesdf
in lmerTest::contest()
assumes mean of weights is 1.augmentPriorCount()
and voomWithDreamWeights()
, add argument scaledByLib=FALSE
BIC()
and .fitExtractVarPartModel()
BIC()
for result of dream()
and lmFit()
logLik()
for result of dream()
and lmFit()
"Satterthwaite"
assign( "[.MArrayLM2",)
rdf < 1
makeContrastsDream()
residuals()
when dividing by sqrt(1-hatvalues)
add small offset to make sure the value is positiveaugmentPriorCount()
prior.count
argument to voomWithDreamWeights()
and feed it to augmentPriorCount()
omp_set_num_threads()
deeper in nestingfit$genes
properlylmFit()
and iterRows()
set scale = FALSE
as defaultvoomWithDreamWeights()
, scale in input weights and weights in side fitVarPartModel()
voomLmFit()
dream()
use rescaleWeights = FALSE
to get sigma
estimates compatable with lmFit()
weights
to be a matrix in voomWithDreamWeights()
rescaleWeightsAfter
argument to voomWithDreamWeights()
fitVarPartModel()
, fitExtractVarPartModel()
, and voomWithDreamWeights()
dream()
, if "Kenward-Roger"
is specified but gives covariance matrix that has poor condition number or is not positive definite, then fall back to "Satterthwaite"
for hypothesis testing in linear mixed modelsfit = dream()
now returns fit$loglik
(the log-likelihood for each gene), and fit$edf
(the effective degreees of freedom for each gene)calcVarPart()
where weights was ignored in some casesmakeContrastsDream()
converts NA
contrasts
to NULL
voomWithDreamWeights(..., span="auto")
now estimates tuning parameter from data using fANCOVA::loess.as()
filterInputData()
now ensures EList contains a matrixmvTest()
when specifying features with stringsmvTest()
to run in parallelmvTest()
to include Hotelling T2 test and LS.empirical()
lmer()
fitdream()
, ensure model convergence using second fitting with Nelder_Mead
to avoid edge cases where the approximate hessian from lmerTest::as_lmerModLT()
has a negative eigenvalueget_prediction()
returning NA values when variables modeled as categorical and levels are omittedvoomWithDreamWeights()
when some genes don't convergelmer()
model fit with another optimizer after it fails convergence test.vcov()
mvTest()
mvTest()
now shrinks covariance using the Schafer-Strimmer methodvcovSqrt()
returns the matrix whose cross product gives the vcov()
result from fits with dream()
dreamlet
package that depends heavily on variancePartition
. makeContrastsDream()
residuals()
mvTest()
with features as listmakeContrastsDream()
by adding droplevels()
diffVar()
now fits contrasts estimated in first stepvcov()
when samples are dropped due to covariate having NA
valuecanCorPairs()
now allows random effects in formulamvTest()
, more consistent return values when one features is usedvcov()
vcov()
in test_vcov2()
topTable()
deviance()
sqrtMatrix()
to have positive diagonaldiffVar()
test of differential variancedream()
now returns formula
, data
, and hatvalues
hatvalues()
for result of dream()
mvTest()
:"FE"
mvTest()
:voomWithDreamWeights()
mvTest()
change option "LS" to "FE"mvTest()
for contrastsvcov()
in order to handle contrastsMArrayLM2
object. cov.coefficients.list
are now named based on gene names mvTest()
vcov()
for results from dream()
mvTest()
for multivariate tests on results from dream()
using vcov()
topTable()
generic to work with R 4.2.1 and Bioc 3.16plotPercentBars
argumentsmakeContrastsDream()
, fix issue where terms with colon cause and errordream()
for variables with NA valuesmakeContrastsDream()
getContrast()
and makeContrastsDream()
make sure formula argument is a formula and not a stringdream()
now drops samples with missing data gracefullyplotStratify()
and plotStratifyBy()
getTreat()
to evaluate treat()
/topTreat()
seamlessly on results of dream()
dream()
set default ddf = "adaptive"
, which uses "KR" for less than 12 samples BPPARAM=SerialParam()
eBayes()
to vignette for dream()
plotPercentBars()
plotPercentBars()
to use generic S4weights
in voomWithDreamWeights()
and add applyQualityWeights()
calcVarPart()
with argument scale=TRUE
allowing the user to disable scaling to fractionsRhpcBLASctl::omp_set_num_threads(1)
to use only 1 OpenMP thread for linear algebra within each BiocParallel processdream()
so useWeights=FALSE
works with lmFit()
voomWithDreamWeights()
makeContrastsDream()
o add plotContrasts()
o Enable random slope models in dream, but not for estimating variance fractions
o export classes to fix bug with class "varPartResults" not being defined
- Thanks Megan Behringer
o Fix issue where if info data.frame contained a column name "gene",
fitExtractVarPartModel() would not run
o Fix tximport issue with eval=FALSE
o Fix vignette
o Fix formatting of vignette
o add description of canCorPairs() function
o Add details to vignette
o add documentation for example datasets
o convert calcVarPart() to S4 from S3 function call
o fix typos in vignette
o fitVarPartModel() and fitExractVarPartModel() use S4 instead of S3 calls
o function now use the precision weights when specified
o Bug update to vignette and simulated data
o plotVarPart() as ylim=c(0,100) as default, and can be changed by user
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