betaparametw: Estimation of proportion weights

In MBttest: Multiple Beta t-Tests

Description

Function betaparametw is used to calculate weight.

Usage

betaparametw(xn, a, b)

Arguments

xn	vector of m library sizes. Library size is sum of counts over the whole library.
a	parameter alpha in beta distribution derived from output of function betaparametab
b	parameter beta in beta distribution derived from output of function betaparametab

Details

alpha and beta are used to calculate weight. Then weight is in turn used to correct bias of estimation of alpha and beta in betaparametab function.

Value

return weight(W)

Author(s)

Yuan-De Tan [e-mail]

References

Baggerly KA, Deng L, Morris JS, Aldaz CM (2003) Differential expression in SAGE: accounting for normal between-library variation. Bioinformatics, 19: 1477-1483.
Yuan-De Tan, Anita M. Chandler, Arindam Chaudhury, and Joel R. Neilson(2015) A Powerful Statistical Approach for Large-scale Differential Transcription Analysis.Plos One. 2015 DOI: 10.1371/journal.pone.0123658.

See Also

betaparametab,betaparametVP.

Examples

XX<-c(2000,2000,2000)
a<-1.1458
b<-6.4932
betaparametw(xn=XX,a=a,b=b)
#[1] 0.3333333 0.3333333 0.3333333

MBttest documentation built on Nov. 8, 2020, 4:57 p.m.