getSimulationPvalue: Function to calculate simulations-based p-values

In MBASED: Package containing functions for ASE analysis using Meta-analysis Based Allele-Specific Expression Detection

Description

Function to calculate simulations-based p-values

Usage

getSimulationPvalue(observedVal, simulatedVals, direction = "greater",
  checkArgs = FALSE)

Arguments

observedVal	observed statistic (single number)
simulatedVals	statistics observed in simulations of the outcomes based on assumed null distribution.
direction	one of 'greater' or 'less', depending on the nature of statistic.
checkArgs	single boolean specifying whether arguments should be checked for adherence to specifications. DEFAULT: FALSE

Details

this function calculates fraction of simulated values (statistics from null distribution) that are >= (direction='greater') or <= (direction='less') than the observed statistic. The choice of direction depends on the nature of the statistic (i.e., direction is 'greater' if large values of statistic indicate departure from null hypothesis, and direction is 'less' if the opposite is the case)

Value

a fraction of simulated statistics that are as or more extreme as the observed one

Examples

MBASED:::getSimulationPvalue(observedVal=2, simulatedVals=1:10, direction='greater')
MBASED:::getSimulationPvalue(observedVal=2, simulatedVals=1:10, direction='less')

MBASED documentation built on Nov. 8, 2020, 5:53 p.m.