initialiseImpulseParameters: Estimate impulse model parameter initialisations

In LineagePulse: Differential expression analysis and model fitting for single-cell RNA-seq data

Description

The initialisations reflect intuitive parameter choices corresponding to a peak and to a valley model and are based natural cubic spline fits in log space with a gaussian noise model.

Usage

initialiseImpulseParameters(vecCounts, lsMuModelGlobal)

Arguments

vecCounts	(count vector number of samples) Count data.
lsMuModelGlobal	(list) Object containing meta-data of gene-wise mean parameter models.

Value

list (length 2)

• peak: (numeric vector number of impulse model parameters) Impulse model parameter initialisation corresponding to a peak.

• valley: (numeric vector number of impulse model parameters) Impulse model parameter initialisation corresponding to a valley.

Author(s)

David Sebastian Fischer

See Also

Called by impulse model fitting wrappers: fitImpulseZINB.

LineagePulse documentation built on Nov. 8, 2020, 7:01 p.m.