README.md

In CoRegNet: CoRegNet : reconstruction and integrated analysis of co-regulatory networks

CoRegNet

CoRegNet is an R/Bioconductor package for gene regulatory network inference and analysis.

It uses a a Shiny/Cytoscape.js interface for the analysis of networks.

Install

From R :

if (!requireNamespace("BiocManager", quietly=TRUE))
    install.packages("BiocManager")
BiocManager::install("CoRegNet")

Quick user guide

1. reconsruct a large-scale regulatory network from a gene expression matrix EXP

GRN = hLICORN(EXP)

1. Infer transcription factor activity

influence = regulatorInfluence(GRN,EXP)

1. Retrieve inferred co-coregulators

coregs= coregulators(GRN,EXP)

1. Analyze the network of cooperative regulators using an interactive display display(GRN,EXP,influence)

CoRegNet documentation built on Nov. 8, 2020, 5:06 p.m.