hill_utils: Functions to solve the Hill model

In philipmorrisintl/GladiaTOX: R Package for Processing High Content Screening data

Functions to solve the Hill model

Description

These functions solve for Hill model parameters.

Usage

gtoxHillACXX(XX, tp, ga, gw, bt = 0)

gtoxHillConc(val, tp, ga, gw, bt = 0)

gtoxHillVal(logc, tp, ga, gw, bt = 0)

Arguments

XX	Numeric, the activity level (percentage of the top value)
tp	Numeric, the top value from the Hill model
ga	Numeric, the logAC50 value from the Hill model
gw	Numeric, the Hill coefficient from the Hill model
bt	Numierc, the bottom value from the Hill model
val	Numeric, the activity value
logc	Numeric, the log concentration

Details

gtoxHillVal computes the value of the Hill model for a given log concentration.

gtoxHillACXX computes the activity concentration for a Hill model for a given activity level.

gtoxHillConc computes the Hill model concentration for a given value.

Value

None

Examples

## The following code gives examples for a Hill model with a top of 50, 
## bottom of 0, AC50 of 1 and Hill coefficient of 1.
## gtoxHillVal calculates activity value given a concentration. gtoxHillVal
## will return the tp/2 when logc equals ga:
gtoxHillVal(logc = 1, tp = 50, ga = 1, gw = 1, bt = 0)

## Here, gtoxHillConc returns the concentration where the value equals 20
gtoxHillConc(val = 20, tp = 50, ga = 1, gw = 1, bt = 0)

## Note how this differs from gtoxHillACXX:
gtoxHillACXX(XX = 20, tp = 50, ga = 1, gw = 1, bt = 0)

## gtoxHillACXX is based on the top value and allows the user to calculate 
## specifc activity concentrations based on a percentage of the top value

## For example, we can calculate the value for the concentration 0.25, then
## use that value to check the other two functions.

value <- gtoxHillVal(logc = 0.25, tp = 50, ga = 1, gw = 1, bt = 0)
c1 <- gtoxHillConc(val = value, tp = 50, ga = 1, gw = 1, bt = 0)
c2 <- gtoxHillACXX(XX = value/50*100, tp = 50, ga = 1, gw = 1, bt = 0)
all.equal(0.25, c1, c2)

## Notice, the value had to be transformed to a percentage of the top value
## when using gtoxHillACXX

philipmorrisintl/GladiaTOX documentation built on Aug. 27, 2023, 9:07 p.m.