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Uses quadratic programming for signature refitting, i.e., to decompose the mutation catalog from an individual tumor sample into a set of given mutational signatures (either Alexandrov-model signatures or Shiraishi-model signatures), computing weights that reflect the contributions of the signatures to the mutation load of the tumor.
Package details |
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Author | Rosario M. Piro [aut, cre], Sandra Krueger [ctb] |
Bioconductor views | BiologicalQuestion BiomedicalInformatics DNASeq Genetics GenomicVariation SNP Sequencing Software SomaticMutation StatisticalMethod |
Maintainer | Rosario M. Piro <rmpiro@gmail.com> |
License | GPL-2 |
Version | 2.6.0 |
URL | http://rmpiro.net/decompTumor2Sig/ https://github.com/rmpiro/decompTumor2Sig |
Package repository | View on Bioconductor |
Installation |
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